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白介素1β(IL1b)活性蛋白

Active Interleukin 1 Beta (IL1b)

IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; Catabolin

  • 白介素1β(IL1b)活性蛋白 产品包装(模拟)
  • 白介素1β(IL1b)活性蛋白 产品包装(模拟)
  • 白介素1β(IL1b)活性蛋白 Figure. Gene Sequencing (Extract)
  • APA563Mu61.png Figure. SDS-PAGE
  • 白介素1β(IL1b)活性蛋白 Figure. Western Blot
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

活性实验

IL-1β (Interleukin-1 beta) is a proinflammatory and immunoregulatory cytokine involved in a variety of cellular activities. It has been elucidated that IL-1β stimulation of cells activates MMP-9 (matrix metalloproteinases-9) secretion by the activation of the dual signalling pathways. Thus, a stimulation assay of IL-1β was conducted using 3T3 cell line, and the MMP-9 activity was detected through gel zymography. Briefly, 1×106 3T3 cells were cultured overnight in 5%DMEM, washed with serum-free medium and then stimulated with different concentrations of IL-1β for 20h, and cell lysates were collected to measure MMP-9 activity. Cell lysates samples were denatured by SDS loading buffer, electrophoresed through sodium dodecyl sulphate–polyacrylamide gel (SDS–PAGE; 10% gels) containing gelatin (1mg/mL) with nonreducing conditions. After renaturation, incubation and coomassiebrilliant blue (CBB)-stained, MMPs hydrolyzed gelatin nearby, indicated by the white binds on the gel.
Result: Increased MMP-9 activity in 3T3 cells due to the stimulation of IL-1β was shown in Figure 1.
Figure. Activation of MMP-9 by IL-1β.

用法

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

储存

避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。

相关产品

编号 适用物种:Mus musculus (Mouse,小鼠) 应用(仅供研究使用,不用于临床诊断!)
RPA563Mu02 白介素1β(IL1b)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
EPA563Mu61 白介素1β(IL1b)真核蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
APA563Mu61 白介素1β(IL1b)活性蛋白 Cell culture; Activity Assays.
RPA563Mu01 白介素1β(IL1b)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
APA563Mu02 白介素1β(IL1b)活性蛋白 Cell culture; Activity Assays.
CPA563Mu11 白介素1β(IL1b)牛血清白蛋白偶联物 Immunogen; SDS-PAGE; WB.
CPA563Mu21 白介素1β(IL1b)卵白蛋白偶联物 Immunogen; SDS-PAGE; WB.
PAA563Mu08 白介素1β(IL1b)多克隆抗体 WB; IHC; ICC; IP.
PAA563Mu01 白介素1β(IL1b)多克隆抗体 WB; IHC; ICC; IP.
PAA563Mu02 白介素1β(IL1b)多克隆抗体 WB; IHC; ICC; IP.
LAA563Mu71 白介素1β(IL1b)多克隆抗体(生物素标记) WB; IHC; ICC.
MAA563Mu21 白介素1β(IL1b)单克隆抗体 WB; IHC; ICC; IP.
MEA563Mu 白介素1β(IL1b)检测试剂盒(酶联免疫吸附试验法,小样本) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA563Mu 白介素1β(IL1b)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA563Mu 白介素1β(IL1b)检测试剂盒(化学发光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
KSA563Mu01 白介素1β(IL1b)检测试剂盒DIY材料(酶联免疫吸附试验法) Main materials for "Do It (ELISA Kit) Yourself".

参考文献

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удк Циток
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The Journal of Thoracic and Cardiovascular Surgery Annexin V homodimer protects against ischemia reperfusion–induced acute lung injury in lung transplantation
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Lipids in Health and Disease Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice.
biomedicine & pharmacotherapy Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation.
International Journal of Molecular Medicine The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats
Springerplus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway
Andrology Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelial dysfunction, oxidative stress, apoptosis, and corporal fibrosis …
Molecular Immunology Targeted inhibition of GATA-6 attenuates airway inflammation and remodeling by regulating caveolin-1 through TLR2/MyD88/NF-κB in murine model of asthma
Cellular Physiology and Biochemistry The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats.
Physiological Research Intravenous dexamethasone attenuated inflammation and influenced apoptosis of lung cells in an experimental model of acute lung injury.
World Journal of Gastroenterology  Alterations in gut microbiota during remission and recurrence of diabetes after duodenal-jejunal bypass in rats
Journal of Orthopaedic Surgery and Research  No midterm advantages in the middle term using small intestinal submucosa and human amniotic membrane in Achilles tendon transverse tenotomy
Molecular Medicine Reports C‑reactive protein/oxidized low density lipoprotein/β2‑glycoprotein i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen‑ …
Poultry Science ALV-J strain SCAU-HN06 induces innate immune responses in chicken primary monocyte-derived macrophages
Molecular Medicine Reports Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects
International Journal of Molecular Sciences PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2
The American Journal of Chinese Medicine Pinellia ternata Attenuates Mucus Secretion and Airway Inflammation after InhaledCorticosteroid Withdrawal in COPD Rats.
The Journal of Comenius University in Bratislava Effects of Conventional Mechanical Ventilation Performed by Two Neonatal Ventilators on the Lung Functions of Rabbits with Meconium-Induced Acute Lung Injury
Journal of Physiology and Pharmacology Effects of budesonide on the lung functions, inflammation and apoptosis in a saline-lavagemodel of acute lung injury.
Cellular Physiology and Biochemistry MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a andRegulating Renal Tubular Cell Pyroptosis.
Oncotarget Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation andapoptosis in diabetic cardiomyopathy.
Life Sciences Bone fracture healing is delayed in splenectomic rats
Sci Total Environ. The effects of particulate matter on inflammation of respiratory system: Differences betweenmale and female.
Food Funct. Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through the MAPK and NF-κB pathways.
PLoS One. Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders.
Cell Death Dis. Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
Journal of Photochemistry and Photobiology B: Biology Efficacy of scaling and root planning with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and gingival crevicular fluid interleukin 1-beta and tumor necrosis factor-alpha levels among patients with periodontal disease: A prospective randomized split-mouth clinical study.
Journal of Cellular Physiology Autophagy maintains the integrity of endothelial barrier in LPS-induced lung injury.
Biomedicine & pharmacotherapy= Biomedecine & pharmacotherapie Protective effects of N-acetylcystein and atorvastatin against renal and hepatic injury in a rat model of intestinal ischemia-reperfusion
Journal of Neurochemistry β‐Caryophyllene protects in vitro neurovascular unit against oxygen‐glucose deprivation and re‐oxygenation‐induced injury
Procalcitonin und proinflammatorische Zytokine in der bronchoalveolären Lavage beim lungenkranken Pferd unter inhalativer Glukokortikoidtherapie
Journal of Agricultural and Food Chemistry Effect of boron on thymic cytokine expression, hormone secretion, antioxidant functions, cell proliferation, and apoptosis potential via the ERK1/2 signaling pathway
PHYSIOLOGICAL RESEARCH Selective Inhibition of NF-κB and Surfactant Therapy in Experimental Meconium-Induced Lung Injury
MOLECULAR MEDICINE REPORTS The effect of anagliptin on intimal hyperplasia of rat carotid artery after balloon injury
Iranian Journal of Basic Medical Sciences Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation in vivo and in vitro
Journal of Cellular Physiology Increased Chondrogenic Potential of Mesenchymal Cells From Adipose Tissue Versus Bone Marrow‐Derived Cells in Osteoarthritic In Vitro Models
Oral Diseases Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis
Biomedicine & Pharmacotherapy Cytokine production in vitro and in rat model of colitis in response to Lactobacillus plantarum LS/07
Food & Function Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264. 7 macrophages through the MAPK and NF-κB …
cellular physiology and biochemistry Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β …
Microbial Immunology Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota
Pesquisa Veterinária Brasileira Efeito protetor do β-glucano e glutamina em lesões intestinais e imunológicas induzidas por ciratabina (Ara-C) em camundongos
Evidence-Based Complementary and Alternative Medicine BuShenKangShuai tablet reduces atherosclerotic lesion by improving blood lipids metabolism and inhibiting inflammatory response via TLR4 and NF-κB signaling pathway
Frontiers in Neurology a-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-觀B Activation and Reduction in Microglia Neuroinflammation.
中国免疫学杂志 b-caryophyllene mitigates cerebral ischemia reperfusion injury in mice by inhibiting HMGB1/ TLR4/ NFkB pathway
Chinese Journal of comparative medicine (中国比较医学杂志) 富氢液通过P13K通路减轻大鼠脑缺血再灌注损伤
PLoS One Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders
Experimentelle periimplantäre Mukositis an unterschiedlichen Implantatoberflächen
International Journal of Biological Macromolecules Chemical composition of Cyclocarya paliurus polysaccharide and inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophage
Journal of Photochemistry and Photobiology B: Biology Efficacy of scaling and root planning with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and gingival crevicular fluid interleukin 1-beta and tumor necrosis factor-alpha levels among patients with periodontal disease: A prospective randomized split-mouth clinical study
Frontiers in Neuroscience Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro
International Journal of Clinical and Experimental Pathology Platelet-derived growth factor and stromal cell-derived factor-1 promote the skin wound repairing effect of bone mesenchymal stem cells: a key role of matrix metalloproteinase 1 and collagens
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis
Cellular Physiology and Biochemistry Dexmedetomidine Alleviates HyperoxiaInduced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation
Tropical Journal of Pharmaceutical Research Protective effect of salvianolic acid B against intestinal ischemia reperfusion-induced injury in a rat model
Frontiers in Molecular Neuroscience Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats
Scientific Reports Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets
Oncotarget Neuroprotection of Botch in experimental intracerebral hemorrhage in rats.
PLoS One Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats
Autonomic Neuroscience Altered gastrointestinal motility in an animal model of Lesch-Nyhan disease.
Endocrine, Metabolic & Immune Disorders-Drug Targets Changes in Serum Nampt Levels and Its Significances in Diabetic Nephropathy Patients-The Potential Role of Nampt in T2DM with Diabetic Nephropathy.
Biological Rhythm Research A study of altered cytokine rhythms associated with successful implantation in cows
Biomedical and Environmental Sciences Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice.
Acta Pharmacologica Sinica Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ.
International journal of molecular medicine Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma
Molecular Medicine Reports Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway
Veterinary microbiology Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses.
Biomedicine & pharmacotherapy Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms
International immunopharmacology Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines
International immunopharmacology Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro
Journal of Neuroinflammation Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage.
Journal of Ethnopharmacology Corydalis hendersonii Hemsl. protects against myocardial injury by attenuating inflammation and fibrosis via NF-κB and JAK2-STAT3 signaling pathways.
Journal of Animal Science and Biotechnology Plasma and cerebrospinal fluid interleukin-1β during lipopolysaccharide-induced systemic inflammation in ewes implanted or not with slow-release melatonin.
Translational Stroke Research Early Inflammatory Response in the Brain and Anesthesia Recovery Time Evaluation After Experimental Subarachnoid Hemorrhage
Journal of Controlled Release Nose-to-brain delivery of insulin enhanced by a nanogel carrier
PLOS Pathogens Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis
Cell Death & Disease AMP-activated protein kinase agonist N 6-(3-hydroxyphenyl) adenosine protects against fulminant hepatitis by suppressing inflammation and apoptosis
Journal of Neuroinflammation Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes
Molecular Neurobiology Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects
Neuropharmacology Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway
Journal of Translational Medicine Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation?
Scientific Reports Mesenchymal stromal cells inhibit NLRP3 inflammasome activation in a model of Coxsackievirus B3-induced inflammatory cardiomyopathy
American Journal of Physiology-Lung Cellular and Molecular Physiology Maternal PUFA omega-3 supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring
Food and Chemical Toxicology Antioxidant, anti-inflammatory and synergistic anti-hyperglycemic effects of Malaysian propolis and metformin in streptozotocin–induced diabetic rats
International Journal of Biological Macromolecules Alcohol accumulation promotes esophagitis via pyroptosis activation
Annals of Intensive Care Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome
British journal of nutrition Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2-dimethylhydrazine-induced rat colorectal …
Frontiers in Neurology Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB …
Journal of Functional Foods Hepatoprotective effect of flavonoid-enriched fraction from Cyclocarya paliurus leaves on LPS/D-GalN-induced acute liver failure
Inflammopharmacology Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB
Food & Function Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the Sirt1/NF-κB signaling pathway
Life Sciences Lipoxin A4 may attenuate the progression of obesity-related glomerulopathy by inhibiting NF-κB and ERK/p38 MAPK-dependent inflammation
Life Sciences Modified porcine surfactant enriched by recombinant human superoxide dismutase for experimental meconium aspiration syndrome
Life Sciences Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways
Brain Research Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway
Molecular Reproduction and Development  A proinflammatory response of bovine endometrial epithelial cells to active sperm in vitro
International Endodontic Journal Inhibition of SOX9 Promotes Inflammatory and Immune Responses of Dental Pulp
International Journal of Molecular Medicine MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing …
International Journal of Molecular Medicine Interleukin-1β induces intercellular adhesion molecule-1 expression, thus enhancing the adhesion between mesenchymal stem cells and endothelial progenitor cells …
Neurochemical Research E3 Ubiquitin Ligase c-cbl Inhibits Microglia Activation After Chronic Constriction Injury
PLoS One Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathway
Ultrasound in Medicine & Biology Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis
BMC Infectious Diseases Development of tissue inflammation accompanied by NLRP3 inflammasome activation in rabbits infected with Treponema pallidum strain Nichols
Journal of Molecular Neuroscience A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related Enzymes
Experimental biology and medicine (Maywood) Shock waves increase pulmonary vascular leakage, inflammation, oxidative stress, and apoptosis in a mouse model
Innate Immunity  Lipoxin A attenuates LPS-induced acute lung injury via activation of the ACE2-Ang-(1-7)-Mas axis
Clinical And Experimental Pharmacology And Physiology  Diallyl sulfide alleviates cisplatin‐induced nephrotoxicity in rats via suppressing NF‐κB downstream inflammatory proteins and p53/Puma signalling pathway
Evidence-based Complementary and Alternative Medicine Bushenkangshuai Tablet Reduces Atherosclerotic Lesion by Improving Blood Lipids Metabolism and Inhibiting Inflammatory Response via TLR4 and NF-κB Signaling …
Evidence-Based Complementary and Alternative Medicine Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus
BMC Veterinary Research Inflammatory pattern of the infrapatellar fat pad in dogs with canine cruciate ligament disease
Molecular Medicine Reports Protective effects of N (2)‑L‑alanyl‑L‑glutamine mediated by the JAK2/STAT3 signaling pathway on myocardial ischemia reperfusion
Molecular Medicine Reports  Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats
Molecular Medicine Reports Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway
Medical Science Monitor Rho Kinase Type 1 (ROCK1) Promotes Lipopolysaccharide-induced Inflammation in Corneal Epithelial Cells by Activating Toll-Like Receptor 4 (TLR4) …
Medical Science Monitor Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats
Medical Science Monitor Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit …
Experimental Lung Research Anti-IL-8 antibody potentiates the effect of exogenous surfactant in respiratory failure caused by meconium aspiration
Human and Experimental Toxicology Neuroprotective effect of agmatine (decarboxylated -arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson's disease
Oncology Letters Hydrogen‑rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus‑activated kinase 2/signal transducer and activator of …
Journal of Maternal-Fetal & Neonatal Medicine Amniotic fluid HIF1α and exosomal HIF1α in cervical insufficiency patients with physical examination-indicated cerclage
Experimental and Therapeutic Medicine S‑adenosyl methionine regulates calcium channels and inhibits uterine smooth muscle contraction in rats with infectious premature delivery through the transient …
Animal Production Science Omega-3 fatty acids and meloxicam supplementation and the incidence and histopathological changes associated with femoral head syndrome in broilers
International Journal of Clinical and Experimental Medicine BoNT-A attenuated pain of endometriosis by inhibiting microglia activation
International Journal of Pharmacology Evaluation of Susceptibility and Innate Immune Response to Candida albicans in Mice with Sub-health
Journal of Diabetes Investigation Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance
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